Dicyclomine, also known as dicycloverine, is an anticholinergic that blocks muscarinic receptors. Dicycloverine was first synthesized in the United States circa 1947.
Dicyclomine is used to treat intestinal hypermotility and the symptoms of Irritable Bowel Syndrome (IBS) (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.
in the UK it is ingredient of a multi-ingredient preparation, together with an antiflatulent (simethicone) and two antacids, under the trade name Kolanticon.
It is also marketed as Meftal-SPAS containing mefenamic acid along with dicyclomine hydrochloride as an analgesic and antispasmodic.
Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea, and, at higher doses, deliriant effects. Recreational use of this drug for its anticholinergic effects has been rarely reported. (read more below)
Breastfeeding is not recommended while using this drug. Users should use care when operating vehicles and/or dangerous machines.
Why is this medication prescribed ?
Dicyclomine is used to treat the symptoms of irritable bowel syndrome. Dicyclomine is in a class of medications called anticholinergics. It relieves muscle spasms in the gastrointestinal tract by blocking the activity of a certain natural substance in the body.
How should this medicine be used?
Dicyclomine comes as a capsule, a tablet, and a syrup to take by mouth. It is usually taken 4 times a day. To help you remember to take dicyclomine, take it around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dicyclomine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor will probably start you on a low dose of dicyclomine and gradually increase your dose.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking dicyclomine,
tell your doctor and pharmacist if you are allergic to dicyclomine or any other medications.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: amantadine (Symmetrel); antacids; antidepressants such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); antihistamines; diet pills; digoxin (Lanoxin); ipratropium (Atrovent); isosorbide (Imdur, Ismo, Isordil, others); medications for anxiety, asthma, glaucoma, irregular heartbeat, mental illness, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems; metoclopramide (Reglan); monoamine oxidase (MAO) inhibitors, including phenelzine (Nardil) and tranylcypromine (Parnate); narcotic pain relievers such as meperidine (Demerol); nitroglycerin (Nitro-Bid, Nitrostat, others); sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have or have ever had glaucoma; ulcerative colitis; an enlarged prostate (prostatic hyperplasia); difficulty urinating; esophageal reflux (heartburn); a blockage in the gastrointestinal tract; myasthenia gravis; high blood pressure; an overactive thyroid gland (hyperthyroidism); nerve disease (autonomic neuropathy); heart failure; rapid or pounding heartbeat; hiatal hernia; or liver, kidney, or heart disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking dicyclomine, call your doctor. Do not breast-feed while taking this medication.
talk to your doctor about the risks and benefits of taking dicyclomine if you are 65 years of age or older. Older adults should not usually take dicyclomine because it is not as safe or effective as other medications that can be used to treat the same condition.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking dicyclomine.
you should know that dicyclomine may make you drowsy or cause blurred vision. Do not drive a car or operate machinery until you know how this medication affects you.
remember that alcohol can add to the drowsiness caused by this medication.
you should know that dicyclomine reduces the body's ability to cool off by sweating. In very high temperatures, dicyclomine can cause fever and heat stroke.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Dicyclomine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
dry mouth , upset stomach , vomiting, constipation, stomach pain, gas or bloating, loss of appetite, dizziness, tingling, headache, drowsiness, weakness, blurred vision, double vision , difficulty urinating
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
hot, flushed, dry skin
confusion , forgetfulness , seeing things or hearing voices that do not exist (hallucinating) unsteadiness , coma , anxiety , excessive tiredness , difficulty falling asleep or staying asleep , excitement , inappropriate mood , muscle weakness , rapid or pounding heartbeat , fainting , hives , skin rash , itching , difficulty breathing or swallowing
Dicyclomine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include the following:
Headache , upset stomach , vomiting , blurred vision , dilated pupils , hot, dry skin , dizziness, dry mouth , difficulty swallowing, nervousness , excitement,
seeing things or hearing voices that do not exist (hallucinating)
What other information should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
BRANDS - CYCLOPAM INJ
Combinations : cyclopam tab (dicyclomin + paracetamol )
meftal spas (dicyclomine +mefenamic acid)
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