HYOSCINE (BUSCOPAN)

HYOSCINE BUTYL BROMIDE (Butylscopolamine)

IUPAC Name  - [7(S)-(1α,2β,4β,5α,7β)]-9-butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa- 9-azonitricyclo[3.3.1.0(2,4)]nonane

Butylscopolamine — also known as scopolamine butylbromide, butylhyoscine and hyoscine butylbromide — is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic. It is a quaternary ammonium compound and a semisynthetic derivative of scopolamine. It is marketed under the trade name Buscopan by Boehringer Ingelheim GmbH, Germany, who also offer a combination of butylscopolamine and paracetamol, marketed under the name Buscopan Plus (in some countries, Buscopan Compositum).

Butylscopolamine is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is also effective at preventing bladder spasms. It is not an analgesic in the normal sense, since it doesn't 'mask' or 'cover over' the pain, but rather works to prevent painful cramps and spasms from occurring in the first place. The attachment of the butyl-bromide moiety effectively prevents the movement of this drug across the blood–brain barrier, effectively minimising undesirable CNS side-effects associated with scopolamine/hyoscine.

MEDICAL USE    -  Butylscopolamine is used to treat cramping abdominal pain with some success.

Hyoscine butylbromide is effective in significantly reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate

Abuse   _  Butylscopolamine is not centrally active and has a low incidence of abuse.

DOSE

ORAL   - SPASM OF INTESTINAL AND BILIARY TRACT; SPASMODIC

DYSMENORRHOEA : Adult 10mg q.i.d

INTRA MUSCULAR  -  UP TO 20mg  repeat if needed after 30 minuts.

AS AID TO RADIOLOGICAL AND ENDOSCOPIC EXAMINATION OF GI TRACT : Adult 20-40mg

BRANDS  -  BUSCOPAN TAB,INJ,SUPPOSITTORY