Thursday, March 28, 2013

BENIDIPINE


Benidipine is a Calcium Antagonist it is also known as Benidipinum or benidipine hydrochloride, It  is a dihydropyridine calcium channel blocker for the treatment of high blood pressure

DOSE  -   2–4 mg once daily .  Should be taken with food.

Benidipine is sold as Coniel by Kyowa Hakko Kogyo.
Benidipine is only licensed for use in Japan and selected Southeast Asian countries, where it is sold as 4 mg tablets.


O5-methyl O3-[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Mechanism of action   :  The vasorelaxant effect of benidipine is due to its affinity towards dihydropyridine binding sites in calcium channels. Binding of benidipine with calcium channels inhibits calcium current. The onset of action is slow, which results in minimal tachycardia or palpitation.

Contraindications     :  Pregnancy and lactation.

Special Precautions   : Elderly. In case of dizziness or lightheadedness, advise patients against handling of heavy machines or working at elevated spots. Reduce dosage gradually while withdrawing drug. Liver function tests.

Adverse Drug Reactions: Palpitation, facial flushing, hot flushes, chest pressure sensation, headache, dizziness, sleepiness, constipation, nausea, abdominal discomfort, oedema, malaise, tinnitus, redness and warm feeling in the fingers, shoulder stiffness, increased frequency of micturition. Hypersensitive reactions e.g. rash and itching. Elevation of SGOT, SGPT, alkaline phosphatase, total bilirubin, creatinine and uric acid.

Drug Interactions     : β-blockers or diuretics may enhance BP control. Serum concentrations of digoxin may be increased. Cimetidine may inhibit benidipine metabolism.

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