Friday, May 9, 2014

Terazosin


Terazosin (marketed as Hytrin or Zayasel) is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It also acts to lower the blood pressure, and is therefore a drug of choice for men with hypertension and prostate enlargement.


It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

Most common side effects include dizziness, drowsiness, headache, constipation, loss of appetite, fatigue, nasal congestion or dry eyes, but they generally go away after only a few days of use. Therapy should always be started with a low dose to avoid first dose phenomenon. Sexual side effects are rare, but may include priapism or erectile dysfunction.

Terazosin hydrochloride is a white, crystalline substance, freely soluble in water and isotonic saline and has a molecular weight of 459.93. HYTRIN tablets (terazosin hydrochloride tablets) for oral ingestion are supplied in four dosage strengths containing terazosin hydrochloride equivalent to 1 mg, 2 mg, 5 mg, or 10 mg of terazosin.

FORMS OF TERAZOSIN
1 mg
Each white, round, flat, bevelled-edged tablet embossed with \"74\" on one side and \"ZA\" on the other, contains terazosin 1 mg (as terazosin HCl). Nonmedicinal ingredients: cornstarch, lactose, magnesium stearate, povidone and talc. Alcohol-, gluten-, paraben-, sodium-, sucrose-, sulfite- and tartrazine-free.

2 mg
Each orange, round, flat, bevelled-edged tablet embossed with \"74\" on one side and \"ZB\" on the other, contains terazosin 2 mg (as terazosin HCl). Nonmedicinal ingredients: cornstarch, FD&C yellow No. 6, lactose, magnesium stearate, povidone and talc. Alcohol-, gluten-, paraben-, sodium-, sucrose-, sulfite- and tartrazine-free.

5 mg
Each tan, round, flat, bevelled-edged tablet embossed with \"74\" on one side and \"ZC\" on the other, contains terazosin 5 mg (as terazosin HCl). Nonmedicinal ingredients: cornstarch, iron oxide, lactose, magnesium stearate, povidone and talc. Alcohol-, gluten-, paraben-, sodium-, sucrose-, sulfite- and tartrazine-free.

10 mg
Each blue, round, flat, bevelled-edged tablet, with \"74\" on one side and \"ZD\" on the other, contains terazosin 10 mg (as terazosin HCl). Nonmedicinal ingredients: cornstarch, FD&C Blue No. 2, lactose, magnesium stearate and talc. Alcohol-, gluten-, paraben-, sodium-, sucrose-, sulfite- and tartrazine-free.
Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.


(RS)-6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine


Pharmacokinetic :
Protein binding     90-94%
Half-life 12 hours


FOR PATIENTS

What are the possible side effects of terazosin (Hytrin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

fast or pounding heartbeats or fluttering in your chest;
feeling like you might pass out;
swelling in your hands, ankles, or feet; or
penis erection that is painful or lasts 4 hours or longer.
Less serious side effects may include:
mild dizziness;  weakness, drowsiness;

BRANDS

  1. Hytrin 1 m Tablet           Abbott India Ltd
  2. Teraz  1mg Tablet          Unichem Laboratories Ltd.
  3. Zytrin (2 mg)Tablet        Stadmed Pvt Ltd
  4. Gotera Tablet                 CMG Biotech Pvt. Ltd.
  5. Hytrin (2 mg)Tablet         Abbott India Ltd
  6. Hytrin (5 mg)Tablet        Abbott India Ltd
  7. Olyster Tablet             Zydus Alidac
  8. Olyster (2 mg)Tablet        Zydus Alidac
  9. Olyster (5 mg)Tablet       Zydus Alidac
  10. Teraban Tablet              Bantom Laboratories (P) Ltd.
  11. Teradip Tablet              Glenmark Pharmaceuticals Ltd.
  12. Teradip (1 mg)Tablet       Glenmark Pharmaceuticals Ltd.
  13. Terakare  Tablet              Medley Pharmaceuticals Pvt. Ltd.
  14. Terakare (2 mg)Tablet      Medley Pharmaceuticals Pvt. Ltd.
  15. Teralfa Tablet              Torrent Pharmaceuticals Ltd.
  16. Teralfa (2 mg)Tablet         Torrent Pharmaceuticals Ltd.
  17. Terapress  Tablet              Intas Pharmaceuticals Ltd.
  18. Terapress (2 mg)Tablet     Intas Pharmaceuticals Ltd.
  19. Terapress (5 mg)Tablet     Intas Pharmaceuticals Ltd.
  20. Teraz (2 mg)Tablet           Unichem Laboratories Ltd.
  21. Teraz (5 mg)Tablet           Unichem Laboratories Ltd.
  22. Unoter Tablet               Pharmacia India Ltd
  23. Unoter (2 mg)Tablet         Pharmacia India Ltd
  24. Unoter (5 mg)Tablet         Pharmacia India Ltd
  25. Vicard-T Tablet                Abbott India Ltd
  26. Vicard-T (2 mg)Tablet      Abbott India Ltd
  27. Zytrin Tablet               Stadmed Pvt Ltd

PRICE LIST

Teradip (1 Mg)

(10 Tablets in Tablet)

Glenmark Pharmaceuticals Ltd

Rs. 3.98/Tablet


Terakare (1 Mg)

(10 Tablets in Tablet)

Vazokare (Medley Pharmaceuticals Limited)

Rs. 5.95/Tablet


Teraban (1 Mg)

(10 Tablets in Tablet)

Bantom Laboratories (P) Ltd.

Rs. 8.30/Tablet


Vicard T (1 Mg)

(10 Tablets in Tablet)

Abbott India Limited

Rs. 8.30/Tablet


Unoter (1 Mg)

(10 Tablets in Tablet)

Pharmacia & Upjohn (India) Pvt Ltd

Rs. 8.30/Tablet


Olyster (1 Mg)

(10 Tablets in Tablet)

Zydus Cadila Healthcare Ltd

Rs. 8.30/Tablet


Prostrin (1 Mg)

(10 Tablets in Tablet)

Lap Farmacia Ltd

Rs. 8.37/Tablet


Terapress (1 Mg)

(7 Tablets in Tablet)

Intas Laboratories Pvt Ltd

Rs. 8.38/Tablet


Gotera (1 Mg)

(10 Tablets in Tablet)

CMG Biotech

Rs. 8.48/Tablet



Zytrin (1 Mg)

(10 Tablets in Tablet)

Stadmed Pvt Ltd

Rs. 9.22/Tablet


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