Amoxicillin (250MG)
INDICATORS
Pregnancy:B Lactation:L1 Lab:NA Food:NA
USE
Respiratory, genito-urinary, skin and soft tissue, ENT infections due to susceptible strains of Gram negative organisms like H.influenzae, E-coli, P.mirabilis and N. gonorrhoea.
SIDE EFFECTS
Abscesses, acute bronchitis, bacteriuria, bronchitis, carbuncles, cellulitis, chronic bronchitis, cystitis, dental abscess, dental abscess (short-course), endocarditis, furunculosis, gonorrhoea, gynecological infections, haemophilus influenzae infections, dizziness, headache, anorexia, iarrhea, fever, abdominal pain, maculopapular rash, rashes, gastritis, indigestion, urticarial skin rash.
DRUG INTERACTION
Amoxicillin is known to interact with other drugs like chloramphenicol, methotrexate, probenecid, rabeprazole, sodium picosulphate, tetracycline (HCl), warfarin (Na).
MECHANISM OF ACTION
Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that amoxicllin interferes with an autolysin inhibitor.
Dicloxacillin (250MG)
INDICATORS
Pregnancy:B Lactation:L3 Lab:NA Food:NA
USE
Pneumonia, infections of the ear, urinary tract
SIDE EFFECTS
Pseudomembranous colitis, GI bleeding, hepatitis, cholestatic jaundice, stevens johnson syndrome, nausea, vomiting, diarrhea, abdominal pain, maculopapular rash, urticaria, phlebitis.
DRUG INTERACTION
Dicloxacillin is known to interact with other drugs like ampicillin, chloramphenicol, probenecid, tetracycline (HCl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Dicloxacillin binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, dicloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
INDICATORS
Pregnancy:B Lactation:L1 Lab:NA Food:NA
USE
Respiratory, genito-urinary, skin and soft tissue, ENT infections due to susceptible strains of Gram negative organisms like H.influenzae, E-coli, P.mirabilis and N. gonorrhoea.
SIDE EFFECTS
Abscesses, acute bronchitis, bacteriuria, bronchitis, carbuncles, cellulitis, chronic bronchitis, cystitis, dental abscess, dental abscess (short-course), endocarditis, furunculosis, gonorrhoea, gynecological infections, haemophilus influenzae infections, dizziness, headache, anorexia, iarrhea, fever, abdominal pain, maculopapular rash, rashes, gastritis, indigestion, urticarial skin rash.
DRUG INTERACTION
Amoxicillin is known to interact with other drugs like chloramphenicol, methotrexate, probenecid, rabeprazole, sodium picosulphate, tetracycline (HCl), warfarin (Na).
MECHANISM OF ACTION
Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that amoxicllin interferes with an autolysin inhibitor.
Dicloxacillin (250MG)
INDICATORS
Pregnancy:B Lactation:L3 Lab:NA Food:NA
USE
Pneumonia, infections of the ear, urinary tract
SIDE EFFECTS
Pseudomembranous colitis, GI bleeding, hepatitis, cholestatic jaundice, stevens johnson syndrome, nausea, vomiting, diarrhea, abdominal pain, maculopapular rash, urticaria, phlebitis.
DRUG INTERACTION
Dicloxacillin is known to interact with other drugs like ampicillin, chloramphenicol, probenecid, tetracycline (HCl). Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Dicloxacillin binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, dicloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
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