Sunday, March 10, 2013

RACECADOTRIL



Racecadotril, also known as acetorphan, is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor. Unlike other medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecretory effect—it reduces the secretion of water and electrolytes into the intestine. It is available in India (It was first introduced in 1993 and is widely used in France) and other European countries, as well as most of South America and some South East Asian countries, but not in the United States. It is sold under the tradenames Hidrasec or, in France, Tiorfan. In Italy it is sold under the tradename Tiorfix.
In india trade names  REDOTTIL, ZEDOTT .
A small randomized controlled trial found racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.
Racecadotril, also known as acetorphan, is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor. Unlike other medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecretory effect—it reduces the secretion of water and electrolytes into the intestine. It is available in India (It was first introduced in 1993 and is widely used in France) and other European countries, as well as most of South America and some South East Asian countries, but not in the United States. It is sold under the tradenames Hidrasec or, in France, Tiorfan. In Italy it is sold under the tradename Tiorfix.
In india trade names  REDOTTIL, ZEDOTT .
A small randomized controlled trial found racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.

Indication & Dosage      
Acute diarrhoea
Adult: 100 mg tid, up to 7 days.

Administration - May be taken with or without food.
Special Precautions  -    Renal insufficiency, pregnancy, lactation.
Adverse Drug Reactions -  Vomiting, nausea, constipation, abdominal pain, thirst, vertigo and headache.



Mechanism of Action
                Racecadotril increases the availability of endogenous opioids (enkephalins) by inhibiting the membrane-bound enkephalinase. These enkephalins activate δ-opioid receptors in the GI tract. This leads to a reduction in cAMP mucosal levels, resulting in a reducted secretion of water and electrolytes in the intestinal lumen.  Onset: Within 30 min.

IUPAC NAME   -   (RS)-benzyl N-[3-(acetylthio)-2-benzylpropanoyl]glycinate
Chemical Formula  - C21-H23-N-O4-S

Molecular Weight  -  385
Therapeutic Categories - Antidiarrheal agent ,  Enkephalinase inhibitor

Foreign Names
Racecadotrilum (Latin)
Racecadotril (German)
Racécadotril (French)
Racecadotrilo (Spanish)
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Brand Names
AD             -  Hetero, India
Aquasec    -  Micro Nova, India
Cadotril    - Medifarma, Peru
Diarfix      -  CristerS, France
Dirasec     -  Abbott, India
Du La Bao  -  Baili Pharmaceutical, China
Enuff          -  Hetero, India
Feng Hai Ting - Zhengda Fenghai Pharmaceutical, China
Hidrasec   - Abbott, China;       Abbott, Philippines;                 Bagó, Ecuador;                Ferrer, Costa Rica; Ferrer, Dominican Republic;          Ferrer, Guatemala;            Ferrer, Honduras;                     Ferrer, Mexico; Ferrer, Nicaragua;    Ferrer, Panama;     Ferrer, El Salvador;    Fournier, Bulgaria;    Fournier, Romania; Galenica, Greece;     Laboratoire Sophartex, Vietnam;      Leti, Venezuela;      Silesia, Chile;  
  Solvay, Thailand
Hidrasec Children (pediatric) -  Fournier, Bulgaria
Hidrasec Infants (pediatric)-Fournier, Bulgaria
Hydral     -  Alembic, India
Lomorest   -  Zuventus, India
Mo Ni Ka   -  Hailing, China
Mold       -  Aversi, Georgia
Pedidot    -  Elder, India
Racaril    -East West, India
Racedot    -  Macleods, Georgia
Race-F     -  Bestochem, India
Racotil    -  Cipla, India
Racy       -  Abbott, India
Redotil    -  Dr. Reddy's, India
Resorcal Lactantes/Ninos (pediatric) - Andromaco, Chile
Resorcal   - Andromaco, Chile
Tiorfan    - Abbott, Germany; Bago, Brazil; Bioproject, Tunisia; Bioprojet, France; CPH, Portugal; Ferrer, Peru; Ferrer Farma, Spain
Tiorfan Infantil - CPH, Portugal
Tiorfan Niños (pediatric) - Ferrer, Peru
Tiorfan nourrissons (pediatric) - Bioproject, Tunisia
Tiorfanor  - Bioprojet, France
Tiorfast   - Bioprojet, France
Tiorfix    - Costanzafarma, Italy
Zomatril   -  FDC, India


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