S-Atenolol is a selectiveBeta-1 Receptor Blocker and Antihypertensive
S-Atenolol selectively blocks the Beta-1 receptors and it significantly reduces both maximal and sub maximal exercise heat rates in a dose-related manner. Entocrine and metabolic actions of S-Atenolol include lowering of plasma rennin activity and free fatty acids.
HYPERTENSION: Adult: Stage 1 Hypertension 12.5-25mg O.D
Stage 2 Hypertension 5mg O.D
ANGINA: Adult: 12.5-25mg O.D
MYOCARDIAL INFARCTION: Adult: 12.5-25mg O.D
Migraine prophylaxis50-100 mg/day.
Contraindications Hypersensitivity, 2nd and 3rd degree heart block, cardiogenic shock, bronchospasm, history of obstructive airway disease, metabolic acidosis, hypotension, severe peripheral arterial disease, sinus bradycardia.
Special Precautions Renal failure, DM, children, pregnancy and lactation. May mask symptoms of hyperthyroidism and hypoglycaemia. Avoid abrupt withdrawal.
Adverse Drug Reactions Fatigue, cold extremities, bradycardia, heart failure, headache, dizziness, hallucinations, confusion and sleep disturbances.
Drug Interactions Disopyramide when given in combination with atenolol depresses myocardial contractility and may precipitate cardiac failure. Efficacy may be antagonised by NSAIDs.
Potentially Fatal: Concurrent use with verapamil may precipitate heart failure in patients with impaired left ventricular function. Simultaneous withdrawal of atenolol and clonidine may result in severe rebound hypertension.
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