Tuesday, July 23, 2013

NEBIVOLOL

Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and, in Europe, also for left ventricular failure. It is highly cardioselective under certain circumstances
Nebivolol slows down the activity of your heart by stopping messages sent by some nerves to your heart. It does this by blocking tiny areas (called beta-adrenergic receptors) where the messages are received by your heart. Nebivolol also relaxes (widens) some blood vessels. These two things together allow the pressure of blood within your blood vessels to be reduced and make it easier for your heart to pump blood around your body. This is of benefit in hypertension (where your blood pressure is too high), and in heart failure (which is a condition where the pumping action of your heart is reduced).
In the US, Nebivolol (nebivolol systemic) is a member of the drug class cardioselective beta blockers and is used to treat High Blood Pressure and Mitral Valve Prolapse.

1-(6-fluorochroman-2-yl)-{[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]amino}ethanol


PHARMACOLOGY
Beta blockers help patients with cardiovascular disease by blocking β receptors, while many of the side-effects of these medications are caused by their blockade of β2 receptors. For this reason, beta blockers that selectively block β1 receptors (termed cardioselective or β1-selective beta blockers) produce fewer adverse effects (for instance, bronchoconstriction) than those drugs that non-selectively block both β1 and β2 receptors. Nebilovol has been marketed by Cipla Ltd under brand name Nebicip; by Forest Laboratories under the name Bystolic; by Micro Labs under the brand name Nebilong; ; and by Menarini under the names Hypoloc, Lobivon, Nebilet, Nebilox, Nobiten, and Temerit. In a laboratory experiment conducted on biopsied heart tissue, nebivolol proved to be the most β1-selective of the β-blockers tested, being approximately 3.5 times more β1-selective than bisoprolol. However, the drug's receptor selectivity in humans is more complex and depends on the drug dose and the genetic profile of the patient taking the medication. The drug is highly cardioselective at 5 mg. However, at doses above 10 mg, nebivolol loses its cardioselectivity and blocks both β1 and β2 receptors. (While the recommended starting dose of nebivolol is 5 mg, sufficient control of blood pressure may require doses up to 40 mg). Furthermore, nebivolol is also not cardioselective when taken by patients with a genetic makeup that makes them "poor metabolizers" of nebivolol (and other drugs) or with CYP2D6 inhibitors. As many as 1 in 10 Whites and even more Blacks are poor CYP2D6 metabolizers and therefore might benefit less from nebivolol's cardioselectivity although currently there are no directly comparable studies

Before taking nebivolol
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking nebivolol it is important that your doctor or pharmacist knows:

If you are pregnant, trying for a baby or breast-feeding.
If you have liver or kidney problems.
If you have low blood pressure or poor circulation.
If you have asthma or breathing difficulties.
If you have diabetes.
If you have psoriasis (a skin problem).
If you have myasthenia gravis (a condition causing muscle weakness).
If you have been told you have a slow heartbeat or heart block (a slow and irregular heartbeat).
If you have been told you have Prinzmetal's angina (chest pain caused by spasms of the heart's blood vessels).
If you have phaeochromocytoma (a tumour on your adrenal gland).
If you are taking other medicines, including those available to buy without a prescription, herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine, or if you have ever had any other severe allergic reaction.


BRANDS

ASIVOL        -           AS PHARMA
BIPINOR            -    ACI  (Bangladesh)
BYSTOLIC          -    Forest (United States)
EBIVOL              -    Actavis Group (Poland)
ENDOLOL          -     Heto       India
EZOCEM            -    OZONE Laboratories        -   Poland, Romania
LOVISPES        -      Specifar SA           Slovenia, Teva, Poland
NEBEST           -    USV               -    India
Nebeta                Abdi Ibrahim, Georgia
Nebicard        Biofarm, Poland;         Hexal, Latvia;        Sandoz, Lithuania;      Torrent, India;     Torrent  -      Vietnam
Nebicard-H             (Nebivolol and Hydrochlorothiazide)           Torrent   -    India
Nebicard-SM       (Nebivolol and Levamlodipine)        Torrent  -  India
Nebicard-V      (Nebivolol and Valsartan)       Torrent  -   India
Nebilet        Adcock Ingram Pharmaceuticals -  South Africa;          Berlin-Chemie  -   Georgia;                Berlin-Chemie -  Tunisia;            Biotoscana -  Peru;                  Menarini -  Costa Rica;                         Menarini  -  Dominican Republic;                      Menarini  -    Honduras;              Menarini  -  Nicaragua;   Menarini  -   Panama;       Menarini  -   El Salvador;                 Menarini Laboratorios  -   Guatemala
Nebilet Plus     (Nebivolol and Hydrochlorothiazide (pediatric))       Berlin-Chemie  -   Georgia
Nebilong       Micro Carsyon  - India
Nebilong-H    (Nebivolol and Hydrochlorothiazide)         Micro Carsyon  -  India
Nebimac      -   Macleods  -   India
Nebimac-H    (Nebivolol and Hydrochlorothiazide)       Macleods  -   India
Nebinad        Farma-Projekt   -  Poland
Nebinex         Glenmark   -  India
Nebinex-AM     (Nebivolol and Amlodipine)         Glenmark  -   India
Nebinorm      Medicament  -   Romania
Nebipil           Alkem  -  India
Nebipril-SA   (Nebivolol and Levamlodipine)      Alkem   -   India
Nebispes      Galex  -   Poland;                Galex  -   Slovenia;        Nycomed  -   Latvia;        Pharmanova -Serbia
Nebistar                Lupin  -  India
Nebistar-SA        (Nebivolol and Levamlodipine)          Lupin  -  India
Nebiten       Anthus  -  India
Nebiten-H     (Nebivolol and Hydrochlorothiazide)               Anthus  -   India
NebivoLek            Sandoz  -    Poland
Nebivolol Actavis         Actavis  -   Romania
Nebivolol AL            Aliud   -  Germany
Nebivolol EG       Eurogenerics  -   Luxembourg
Nebivolol Hexal           1A Pharma  -   Poland;       Hexal  -   Luxembourg
Nebivolol Mylan        Generics  -  Slovenia
Nebivolol Pliva          Pliva   -  Poland
Nebivolol Teva            Teva   -  Romania
Nebivor           Orion  -   Poland
Neblotensol           Gerot-Lannach  -  Romania
Nedal     Polfa Warszawa  -   Poland
Nemirostad         STADA     Lithuania
Nemont        Norameda  - Lithuania
Nerose         Norameda  -  Lithuania
Nevol            Medley  -   India
Nevol-H(Nebivolol and Hydrochlorothiazide)          Medley  -   India
Niavas         Ranbaxy   -   India
Niavas-D(Nebivolol and Hydrochlorothiazide)                     Ranbaxy  -   India
Nobiten           Menarini   -   Luxembourg
Nobizide(Nebivolol and Hydrochlorothiazide)      Menarini International-L      -    Italy
Nolet                 Antibiotice    -   Romania
Nonblon             Aversi     -  Georgia
Nonblon H   (Nebivolol and Hydrochlorothiazide)          Aversi  -   Georgia
Nubeta         Abbott  -   India
Nubeta-H      (Nebivolol and Hydrochlorothiazide)       Abbott  -   India
Nubeta-SM       (Nebivolol and Levamlodipine)     Abbott   -   India
X-Pressol          Labormed Pharma  Romania
Zenebi         FDC    India
Zinebi        FDC  -   India
Anfibol      Drugtech   Chile
Betalol       East West   India
Betalol-H     (Nebivolol and Hydrochlorothiazide)         East West  -   India
Bivol       Specifar  -  Greece
Bravylol      -   Tchaikapharma  -  Bulgaria
Conébilox       (Nebivolol and Hydrochlorothiazide)         Negma  -  France
Ezocem    S.C. Labormed Pharma   -   Czech Republic
Hypoloc      Berlin-Chemie   -   Germany;             Menarini  -   Austria;                   Menarini -  Denmark;   Menarini   -  Finland;                  Menarini    -   Greece;             Menarini  -   Luxembourg;                  Menarini   -      Netherlands
Lobibeta       Alet Pharmaceuticals   -   Greece
Lobivon Plus    (Nebivolol and Hydrochlorothiazide)           Menarini  -  Spain   
Lobivon       Berlin-Chemie   -  Germany;              Menarini  -  Spain;                Menarini     -   Greece; Menarini   -   Italy;                   Menarini    Netherlands
Nabila       Tecnofarma  -  Chile
Nebalex      Specifar   -   Bulgaria
Nebest-H      (Nebivolol and Hydrochlorothiazide)       USV  -   India
Nebicar           OEP Phils   -   Philippines
Nebicard       Medicamenta  -   Bulgaria;       Sandoz-  Estonia;        Torrent  -   Myanmar;                    Torrent  -  Philippines
Nebicor        Adipharm -  Bulgaria
Nebicur        Kleva     Greece
Nebilan      G.L. Pharma  -   Bulgaria;                 Lannacher  -   Austria
Nebilet plus  (Nebivolol and Hydrochlorothiazide)     Menarini  -   Lithuania;    Menarini  -  Latvia;    Menarini  -   Malta
Nebilet
A. Menarini  -   United Kingdom;     Berlin Chemie  -   Bosnia & Herzegowina;        Berlin-Chemie, Bulgaria;     Berlin-Chemie, Czech Republic;             Berlin-Chemie -  Germany;            Berlin-Chemie  -   Croatia (Hrvatska);    Berlin-Chemie  - Hungary;              Berlin-Chemie -  Poland;                Berlin-Chemie, Romania;         Berlin-Chemie, Serbia;          Berlin-Chemie   -   Slovakia;                   Biotoscana, Colombia; CSL, Australia; ITF – Labomed   Chile;       Leti  -   Venezuela;      Menarini, Argentina; Menarini, Switzerland; Menarini, Estonia; Menarini  -  Ireland;       Menarini  -  Lithuania;      Menarini  -   Latvia;      Menarini  -  Malta;       Menarini  -   Netherlands; Menarini, Portugal; Menarini, Singapore; Menarini, Slovenia;      Menarini, Thailand
Nebilet Plus (Nebivolol and Hydrochlorothiazide)        Berlin-Chemie, Bulgaria; Menarini, Estonia
Nebilet plus(Nebivolol and Hydrochlorothiazide)          Menarini, Switzerland
Nebiloc      Menarini, Netherlands
Nebilostad      STADA, Netherlands
Nebilox       Berlin-Chemie, Germany; GlaxoSmithKline, Italy
Nébilox       Negma, France
Nebinorm          Glenmark, Lithuania; Medicamenta, Czech Republic
Nebiphar          Teva, Estonia; Teva, Lithuania; Teva, Latvia
Nebirod        Sopharma, Bulgaria
Nebisam     Specifar, Lithuania; Specifar, Latvia
Nebiscal              +pharma, Czech Republic
Nebiscop        Specifar, Estonia; Specifar, Lithuania; Specifar, Latvia
Nebispes        Galex, Czech Republic; Nycomed, Lithuania; Specifar, Estonia
Nebiten                  G.L. Pharma, Estonia; G.L. Pharma, Lithuania; Lannacher Heilmittel, Latvia
Nebitrix      Glenmark, Bulgaria; Glenmark, Czech Republic
Nebivolol - 1 A Pharma               1A Pharma, Germany
Nebivolol +pharma                    +pharma, Czech Republic
Nebivolol 1A Pharma        1A Pharma, Estonia; 1A Pharma, Lithuania
Nebivolol AAA                     AAA-Pharma, Germany
Nebivolol AbZ        AbZ-Pharma, Germany
Nebivolol Actavis       Actavis, Switzerland; Actavis, Bulgaria; Actavis, Estonia; Actavis, United Kingdom; Actavis, Lithuania; Actavis, Latvia; Actavis, Malta; Actavis, Netherlands
Nébivolol Actavis      Actavis, France
Nebivolol Apotex       Apotex, Spain; Apotex Europe, Netherlands
Nébivolol Arrow        Arrow, France
Nebivolol Axapharm      Axapharm, Switzerland
Nébivolol Biogaran    Biogaran, France
Nebivolol CF       Centrafarm, Netherlands
Nebivolol Cinfa         Cinfa, Spain
Nébivolol CristerS     CristerS, France
Nebivolol Dival       Dival Classics, Netherlands
Nebivolol Edigen       Germed, Spain
Nébivolol EG     EG Labo, France
Nébivolol Evolugen       Evolupharm, France
Nebivolol G.L.         G.L. Pharma, Austria
Nebivolol Generis       Generis, Portugal
Nebivolol Glenmark       Glenmark, Netherlands
Nebivolol Heumann        Heumann, Germany
Nebivolol HEXAL          Hexal, Germany
Nébivolol Isomed           Teva Santé, France
Nebivolol Labesfal                     Labesfal, Portugal
Nebivolol Mylan                  Mylan, Spain; Mylan, Netherlands
Nébivolol Mylan                   Mylan, France
Nebivolol Normon              Normon, Spain
Nebivolol Orion                  Orion, Estonia; Orion, Lithuania; Orion, Latvia
Nebivolol PCH         Pharmachemie, Netherlands
Nebivolol Pensa                Pensa Pharma, Spain
Nebivolol Pliva      Pliva, Croatia (Hrvatska); Pliva, Hungary
Nebivolol Portfarma         Portfarma, Estonia; Portfarma, Lithuania; Portfarma, Latvia
Nébivolol Qualimed           Qualimed, France
Nébivolol Ranbaxy             Ranbaxy, France
Nebivolol Ratio                      Ratiopharm, Spain
Nebivolol Ratiopharm               Ratiopharm, Spain
Nébivolol Ratiopharm               Ratiopharm, France
Nebivolol Sandoz           Sandoz, Bulgaria; Sandoz, Switzerland; Sandoz, Czech Republic; Sandoz, Germany; Sandoz, United Kingdom; Sandoz, Netherlands; Sandoz Farmaceutica, Spain
Nébivolol Sandoz            Sandoz, France
Nebivolol Spirig                Spirig HealthCare, Switzerland
Nebivolol STADA                       STADA, Germany
Nebivolol Streuli                      Streuli Pharma, Switzerland
Nebivolol Teva             Teva, Bulgaria
Nébivolol Teva              Teva Santé, France
Nebivolol Tevagen                       Teva, Spain
Nebivolol Torrent                  Torrent Pharma, Lithuania
Nebivolol Winthrop                Winthrop Pharmaceuticals, United Kingdom
Nébivolol Winthrop                 Sanofi-Aventis, France
Nebivolol Zentiva                   Sanofi Aventis, Spain
Nébivolol Zydus                    Zydus, France
Nebivolol/Alapis Bulgaria            Alapis, Bulgaria
Nebivolol-1A Pharma                        1A Pharma, Latvia
Nebivolol-Acino                      Acino, Germany
Nebivolol-aconitum             Aconitum, Lithuania
Nebivolol-Actavis             Actavis, Germany
Nebivolol-CT                      CT Arzneimittel, Germany
Nebivolol-Mepha          Mepha, Switzerland
Nebivololo Actavis         Actavis Italy, Italy
Nebivololo Alter              Alter, Italy
Nebivololo Angenerico                  Angenerico, Italy
Nebivololo Doc Generici         DOC Generici, Italy
Nebivololo Dr Reddy's             Dr Reddy's, Italy
Nebivololo EG               EG, Italy
Nebivololo Mylan                Mylan, Italy
Nebivololo Pensa                 Pensa Pharma, Italy
Nebivololo Ranbaxy          Ranbaxy Italia, Italy
Nebivololo Ratiopharm        Ratiopharm Italia, Italy
Nebivololo Sandoz                 Sandoz, Italy
Nebivololo Teva                     Teva Italia, Italy
Nebivololo Winthrop             Winthrop Ph.Italia, Italy
Nebivolol-ratiopharm             Merckle, Bulgaria;              Merckle, Estonia;           Ratiopharm, Germany; Ratiopharm, Latvia
Nebivolol-Tchaikapharma          Tchaikapharma, Bulgaria
Nebivolol-Teva                         Teva, Germany;           Teva, Estonia;       Teva, Lithuania;          Teva, Latvia; Teva Pharma, Switzerland
Nebizita                       Specifar, Bulgaria
Nemirostad                STADA, Estonia; STADA, Latvia
Nexivol                       Abdi Ibrahim, Turkey
Nibel                        Belupo, Croatia (Hrvatska)
Nobiten                  Menarini, Belgium
Nomexor               Menarini, Austria
Nomexor plus HCT(Nebivolol and Hydrochlorothiazide)     Menarini, Austria
Noviblock     Medicamerc, Greece
Pertium       Saval, Chile
Silostar Plus(Nebivolol and Hydrochlorothiazide)          Uriach-Aquilea, Spain
Silostar                     Uriach-Aquilea, Spain
Temerit                    Menarini, France
TemeritDuo(Nebivolol and Hydrochlorothiazide)        Menarini, France
Vasoxen          I.E. Ulagay, Turkey
Volone             Farmal, Croatia (Hrvatska)



No comments:

Post a Comment